B-cell malignancies are a group of cancers that originate from B-cells, a type of white blood cell responsible for producing antibodies. These malignancies include conditions such as non-Hodgkin lymphoma, Hodgkin lymphoma, and chronic lymphocytic leukemia. They can disrupt the normal functioning of the immune system and may lead to symptoms like swollen lymph nodes, fatigue, and frequent infections. Diagnosis typically involves blood tests, imaging studies, and sometimes a biopsy of affected tissues. Treatment options vary based on the specific type and stage of the malignancy and may include chemotherapy, radiation therapy, or targeted therapies. Early detection and appropriate management are crucial for improving outcomes.