Autoinflammatory diseases are a group of disorders characterized by recurrent episodes of inflammation without the presence of autoimmune antibodies. These conditions arise from genetic mutations that affect the body's innate immune system, leading to uncontrolled inflammation. Common symptoms include fever, rash, and joint pain, which can vary in severity and duration. Examples of autoinflammatory diseases include Familial Mediterranean Fever and Cryopyrin-Associated Periodic Syndromes. Diagnosis often involves clinical evaluation and genetic testing. Treatment typically focuses on managing symptoms and may include medications that reduce inflammation, such as nonsteroidal anti-inflammatory drugs (NSAIDs) or biologics.