ADAMTS3 is a protein that belongs to the ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) family. It plays a crucial role in the processing of extracellular matrix components, particularly in the regulation of vascular endothelial growth factor (VEGF) and angiogenesis, which is the formation of new blood vessels. This protein is primarily expressed in various tissues, including the skin and blood vessels. Mutations or dysregulation of ADAMTS3 can lead to various health issues, including problems with tissue repair and development, highlighting its importance in maintaining normal physiological functions.