The expression "48x12" represents a multiplication problem where 48 is multiplied by 12. This operation is a basic arithmetic calculation that results in the total number of items when 48 groups of 12 items each are combined. The answer to this multiplication is 576. In practical terms, this calculation can be applied in various scenarios, such as determining the total number of seats in a theater with 48 rows and 12 seats per row. Understanding multiplication helps in everyday tasks, such as budgeting or measuring, making it a fundamental skill in mathematics.