The expression "2 × 2 × 5 × 61" represents a multiplication of four numbers. To simplify, we can first multiply the smaller numbers: 2 × 2 equals 4, and then 4 × 5 equals 20. Finally, multiplying 20 by 61 gives us the final result of 1,220. This calculation can be useful in various contexts, such as determining the total number of items when organizing groups. For example, if you have 2 boxes, each containing 2 stacks of 5 items, and each stack has 61 items, you can quickly find the total number of items using this multiplication.