Life in the 16th century varied greatly depending on social class and location. Most people lived in rural areas, working as farmers or laborers. They relied on agriculture for food, growing crops like wheat and barley. Towns were small, and trade began to flourish, leading to the rise of a merchant class. In cities, the Renaissance sparked advancements in art and science, with figures like Leonardo da Vinci and Michelangelo making significant contributions. Education became more accessible, and the invention of the printing press allowed for the spread of ideas. However, life was often harsh, with limited medical knowledge and frequent outbreaks of disease.