The year 1526 is significant in history for several reasons, particularly in the context of the Mughal Empire in India. It marks the beginning of the Mughal rule when Babur, a descendant of Timur and Genghis Khan, defeated the Sultan of Delhi, Ibrahim Lodi, at the Battle of Panipat. This victory established the Mughal dynasty, which would go on to shape Indian culture and politics for centuries. Additionally, 1526 is notable for the Spanish conquest of the Aztec Empire, which began in the early 16th century. This period saw the expansion of European powers in the Americas, leading to significant cultural and demographic changes. The events of this year contributed to the rise of colonialism and the global exchange of goods and ideas.