The years 1452 to 1519 mark the life of Leonardo da Vinci, a prominent Italian artist, scientist, and inventor. Born in Vinci, Italy, in 1452, he became a key figure of the Renaissance, a period known for its advancements in art, science, and culture. Da Vinci is celebrated for masterpieces like the Mona Lisa and The Last Supper, showcasing his exceptional talent in painting and understanding of human anatomy. During this time, Europe experienced significant changes, including the rise of humanism and exploration. The invention of the printing press around 1440 by Johannes Gutenberg revolutionized the spread of knowledge. This era also saw the voyages of explorers like Christopher Columbus, who discovered the Americas in 1492, expanding the world's geographical understanding.