Transthyretin amyloidosis is a rare disease caused by the buildup of abnormal proteins called amyloids in the body. These proteins are formed from a protein known as transthyretin, which is produced in the liver. When transthyretin misfolds, it can aggregate and deposit in various tissues and organs, leading to damage and dysfunction. The condition can manifest in two main forms: hereditary and wild-type. Hereditary transthyretin amyloidosis is passed down through families, while wild-type occurs without a family history. Symptoms may include heart problems, nerve damage, and issues with the kidneys, making early diagnosis and treatment crucial for managing the disease.