A thrombotic stroke occurs when a blood clot, or thrombus, forms in one of the arteries supplying blood to the brain. This blockage prevents oxygen and nutrients from reaching brain cells, leading to cell damage or death. Thrombotic strokes are often associated with conditions like atherosclerosis, where fatty deposits build up in the arteries. There are two main types of thrombotic strokes: large vessel and small vessel strokes. Large vessel strokes affect major arteries, while small vessel strokes impact smaller, deeper arteries. Risk factors include high blood pressure, diabetes, and high cholesterol, which can contribute to clot formation.