Thiazolidinediones (TZDs) are a class of medications used to treat type 2 diabetes. They work by improving the body's sensitivity to insulin, which helps lower blood sugar levels. TZDs target specific receptors in fat and muscle cells, promoting better glucose uptake and storage. Common examples of TZDs include pioglitazone and rosiglitazone. While effective in managing blood sugar, these medications may have side effects, such as weight gain and an increased risk of heart issues. Therefore, they are typically prescribed alongside lifestyle changes like diet and exercise for optimal diabetes management.