Systemic scleroderma, also known as systemic sclerosis, is a chronic autoimmune disease that affects the connective tissues in the body. It leads to the hardening and tightening of the skin and can also impact internal organs, such as the heart, lungs, and kidneys. The exact cause is unknown, but it involves an overproduction of collagen, which is a protein that provides structure to the skin and organs. Symptoms of systemic scleroderma can vary widely among individuals and may include skin changes, joint pain, and digestive issues. Early diagnosis and management are crucial to help control symptoms and prevent complications. Treatment often involves medications to manage symptoms and improve quality of life.