Systemic infections occur when pathogens, such as bacteria or viruses, spread throughout the body, affecting multiple organs or systems. Unlike localized infections, which are confined to one area, systemic infections can lead to severe health complications and may require immediate medical attention. Common examples include sepsis and bacteremia. These infections often arise from untreated localized infections or can be introduced through medical procedures. Symptoms may include fever, chills, fatigue, and confusion. Early diagnosis and treatment are crucial to prevent serious outcomes, making awareness of systemic infections important for overall health management.