"Star-crossed lovers" refers to two individuals whose romantic relationship is doomed to fail due to external circumstances. This term often implies that fate or destiny plays a significant role in their struggles, suggesting that despite their deep love for each other, forces beyond their control prevent them from being together.
The phrase is famously associated with William Shakespeare's play Romeo and Juliet, where the two main characters come from feuding families. Their love story highlights the tragic consequences of societal pressures and family conflicts, illustrating how love can be thwarted by circumstances that seem insurmountable.