A splenic biopsy is a medical procedure used to obtain a small sample of tissue from the spleen. This is typically done to diagnose conditions such as infections, tumors, or blood disorders. The procedure can be performed using imaging guidance, such as ultrasound or CT scans, to ensure accuracy. During the biopsy, a thin needle is inserted into the spleen to collect the tissue sample. The procedure is usually done under local anesthesia, and patients may experience mild discomfort. After the sample is taken, it is sent to a laboratory for analysis to help determine the underlying health issue.