Soluble guanylyl cyclase (sGC) is an enzyme found in various tissues throughout the body. It plays a crucial role in the signaling pathways that regulate blood vessel dilation and smooth muscle relaxation. sGC is activated by the molecule nitric oxide (NO), which is produced by endothelial cells and acts as a signaling molecule. Once activated, sGC converts guanosine triphosphate (GTP) into cyclic guanosine monophosphate (cGMP). This cGMP acts as a secondary messenger, leading to various physiological effects, including vasodilation and inhibition of platelet aggregation. The proper functioning of sGC is essential for maintaining cardiovascular health.