Secondary adrenal insufficiency occurs when the body doesn't produce enough hormones from the adrenal glands due to a problem with the pituitary gland. This gland, located at the base of the brain, normally signals the adrenal glands to produce hormones like cortisol. If the pituitary gland is damaged or not functioning properly, it can lead to a decrease in hormone production, resulting in symptoms such as fatigue, weakness, and low blood pressure. Unlike primary adrenal insufficiency, which involves direct damage to the adrenal glands, secondary adrenal insufficiency is often caused by factors like long-term use of corticosteroid medications or pituitary disorders. Treatment typically involves hormone replacement therapy to restore normal hormone levels and alleviate symptoms.