A "screen reader-friendly" design means that a website or application is built to be easily navigated and understood by software called a screen reader. This software converts text and other visual elements into speech or braille, allowing individuals with visual impairments to access digital content effectively. To be screen reader-friendly, websites should use proper HTML markup, including headings, lists, and alternative text for images. This ensures that the content is structured logically, making it easier for users to find information and interact with the site.