Scrapie is a contagious and fatal disease that affects the nervous system of sheep and goats. It is caused by abnormal proteins called prions, which lead to brain damage and behavioral changes. Infected animals may show signs such as itching, weight loss, and uncoordinated movements. The disease is primarily transmitted through direct contact with infected animals or their bodily fluids. Scrapie is not known to infect humans, but it is closely monitored in livestock populations to prevent its spread. Control measures include culling infected animals and implementing strict biosecurity practices on farms.