Rilpivirine is an antiretroviral medication used to treat HIV infection. It belongs to a class of drugs known as non-nucleoside reverse transcriptase inhibitors (NNRTIs). Rilpivirine works by blocking the reverse transcriptase enzyme, which is essential for the replication of the HIV virus in the body. This medication is typically taken once daily, often in combination with other antiretroviral drugs to enhance its effectiveness. Rilpivirine is known for its favorable side effect profile compared to some other HIV treatments, making it a suitable option for many patients managing their condition.