Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) are a class of antiretroviral drugs used to treat HIV infections. They work by binding to the reverse transcriptase enzyme, which is crucial for the replication of the virus. By inhibiting this enzyme, NNRTIs prevent the virus from converting its RNA into DNA, thereby halting its ability to multiply in the body. NNRTIs are often used in combination with other antiretroviral medications to enhance treatment effectiveness. Common examples of NNRTIs include efavirenz, rilpivirine, and nevirapine. These medications are typically taken orally and are an essential part of HIV treatment regimens.