Retinoid X receptors (RXRs) are a type of nuclear receptor that play a crucial role in regulating gene expression. They are activated by retinoids, which are derivatives of vitamin A. RXRs can form heterodimers with other nuclear receptors, such as thyroid hormone receptors and steroid hormone receptors, to modulate various biological processes, including development, metabolism, and cell differentiation. These receptors are found in many tissues throughout the body and are involved in several signaling pathways. RXRs help control the transcription of genes that influence cellular functions, making them important for maintaining overall health. Dysregulation of RXR activity can lead to various diseases, including certain types of cancer.