Red man syndrome is a reaction that can occur when a person receives the antibiotic vancomycin too quickly through an intravenous (IV) infusion. Symptoms include flushing, rash, and itching, particularly on the face, neck, and upper body. This reaction is not an allergic response but rather a result of the release of histamine in the body. To prevent red man syndrome, healthcare providers often administer vancomycin slowly, typically over at least 60 minutes. If symptoms occur, slowing the infusion or administering antihistamines can help alleviate discomfort. Recognizing and managing this syndrome is important for patient safety during treatment.