Primase is an enzyme that plays a crucial role in DNA replication. It synthesizes short RNA primers, which are necessary for starting the replication process. These primers provide a starting point for DNA polymerase, the enzyme responsible for adding nucleotides to form a new DNA strand. During DNA replication, primase ensures that the replication fork can proceed efficiently. It creates these RNA primers on the single-stranded DNA template, allowing DNA polymerase to extend the new DNA strand. Without primase, DNA replication would be unable to initiate, making it essential for cell division and genetic inheritance.