ornithine transcarbamylase
Ornithine transcarbamylase (OTC) is an enzyme found in the liver that plays a crucial role in the urea cycle. This cycle is responsible for removing ammonia, a toxic byproduct of protein metabolism, from the body. OTC catalyzes the reaction between ornithine and carbamoyl phosphate to produce citrulline, which is essential for the conversion of ammonia into urea.
Deficiencies in OTC can lead to a condition known as ornithine transcarbamylase deficiency, which can cause a buildup of ammonia in the bloodstream. This can result in serious health issues, including neurological damage and metabolic disturbances. Early diagnosis and treatment are vital for managing this condition effectively.