ochronosis
Ochronosis is a rare condition characterized by the accumulation of a dark pigment called homogentisic acid in connective tissues. This occurs due to a genetic disorder known as alkaptonuria, where the body cannot properly break down certain amino acids. As a result, individuals may experience darkening of the urine, joint pain, and changes in skin color.
The condition can lead to serious complications, including arthritis and heart problems, as the pigment deposits can affect various organs and tissues over time. Diagnosis typically involves urine tests to detect elevated levels of homogentisic acid, and management focuses on alleviating symptoms and preventing complications.