Nuclear hormone receptors are a class of proteins that function as transcription factors, regulating the expression of specific genes in response to hormones. They are located in the cell nucleus and bind to steroid hormones, thyroid hormones, and other signaling molecules, allowing them to influence various biological processes such as metabolism, development, and immune response. These receptors play a crucial role in cellular communication and homeostasis. When a hormone binds to a nuclear hormone receptor, it undergoes a conformational change, enabling it to interact with DNA and promote or inhibit the transcription of target genes. Examples of nuclear hormone receptors include estrogen receptors and thyroid hormone receptors.