Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are a class of antiviral drugs used primarily to treat HIV infections. They work by binding to the reverse transcriptase enzyme, which is essential for the replication of the virus. By inhibiting this enzyme, NNRTIs prevent the virus from converting its RNA into DNA, thereby halting its ability to multiply. NNRTIs are often used in combination with other antiretroviral medications to enhance treatment effectiveness and reduce the risk of drug resistance. Common examples of NNRTIs include efavirenz, nevirapine, and rilpivirine. These medications are typically taken orally and are an important part of HIV therapy regimens.