Non-depolarizing refers to a type of neuromuscular blocking agent used in medical settings, particularly during surgeries. These agents work by blocking the transmission of nerve impulses to muscles without causing initial muscle contraction, allowing for muscle relaxation. This is crucial for procedures that require complete muscle control. Unlike depolarizing agents, which cause a brief contraction before paralysis, non-depolarizing agents maintain a steady state of muscle relaxation. Common examples include pancuronium and vecuronium. These medications are typically administered intravenously and are reversed with specific antidotes when the procedure is complete.