Neuromuscular blockers are medications that temporarily paralyze muscles by blocking the transmission of nerve impulses at the neuromuscular junction. They are commonly used during surgical procedures to facilitate intubation and ensure muscle relaxation, allowing surgeons to operate more effectively. These drugs work by inhibiting the action of acetylcholine, a neurotransmitter that signals muscles to contract. There are two main types: depolarizing and non-depolarizing blockers. While depolarizing blockers cause a brief muscle contraction followed by paralysis, non-depolarizing blockers prevent muscle contraction altogether. Their effects can be reversed with specific medications when surgery is complete.