Neurokinin-1 (NK1) is a receptor in the body that primarily binds to a substance called substance P. This receptor is part of the neurokinin family and plays a crucial role in transmitting pain signals, regulating mood, and influencing stress responses. It is found in various tissues, including the brain and spinal cord. Research on neurokinin-1 has led to the development of medications that target this receptor, which may help treat conditions like depression, anxiety, and chronic pain. By blocking NK1, these treatments aim to alleviate symptoms associated with these disorders, highlighting its importance in neuroscience and pharmacology.