Negative inotropes are medications that decrease the strength of heart muscle contractions. They are often used to manage conditions like heart failure or hypertension, where reducing the workload on the heart can be beneficial. By lowering the force of contraction, these drugs help to prevent the heart from becoming overworked. Common examples of negative inotropes include beta-blockers and calcium channel blockers. These medications can help improve heart function and reduce symptoms by allowing the heart to pump more efficiently. However, they must be used carefully, as they can also lead to decreased heart rate and blood pressure.