Loss of pigmentation refers to a decrease in the color of the skin, hair, or eyes due to a reduction in the production of melanin, the pigment responsible for coloration. This condition can occur in various forms, such as vitiligo, where patches of skin lose their color, or albinism, a genetic condition that affects the entire body. The causes of loss of pigmentation can vary, including autoimmune disorders, genetic factors, or environmental influences. It can affect individuals of any age and may lead to increased sensitivity to sunlight, as the skin lacks the protective effects of melanin.