Lipodystrophy is a medical condition characterized by abnormal distribution of body fat. Individuals with lipodystrophy may experience loss of fat in certain areas, such as the arms and legs, while accumulating fat in others, like the abdomen or face. This can lead to a range of health issues, including insulin resistance and increased risk of type 2 diabetes. The condition can be genetic or acquired, often linked to factors such as HIV treatment or metabolic disorders. Diagnosis typically involves physical examination and imaging studies. Management may include lifestyle changes, medications, or treatments to address associated health risks.