Junctional epidermolysis bullosa (JEB) is a rare genetic skin disorder characterized by fragile skin that blisters easily. This condition occurs due to mutations in genes responsible for producing proteins that help anchor the skin layers together. As a result, even minor friction or trauma can lead to painful blisters and sores. JEB is typically present at birth or develops in early childhood. The severity of the condition can vary, with some individuals experiencing mild symptoms while others may face more serious complications. Treatment focuses on wound care, pain management, and preventing infections to improve the quality of life for those affected.