Intestinal stem cells are specialized cells located in the lining of the intestine. They play a crucial role in maintaining the health of the gut by continuously producing new cells to replace those that are damaged or lost. This regeneration is essential for proper digestion and nutrient absorption. These stem cells reside in specific areas called crypts of Lieberkühn, where they divide and differentiate into various cell types, including enterocytes, goblet cells, and Paneth cells. This process ensures that the intestinal lining remains intact and functional, supporting overall digestive health.