Human herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma-associated herpesvirus (KSHV), is a virus that belongs to the herpesvirus family. It is primarily associated with certain cancers, including Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman disease. HHV-8 is transmitted through saliva, sexual contact, and possibly other bodily fluids. Most people infected with HHV-8 do not show symptoms, but the virus can remain dormant in the body. In individuals with weakened immune systems, such as those with HIV/AIDS, HHV-8 can reactivate and lead to serious health issues. Early detection and treatment are important for managing related conditions.