Glutamine-PRPP amidotransferase is an enzyme that plays a crucial role in the synthesis of purines, which are essential components of DNA and RNA. It catalyzes the conversion of phosphoribosyl pyrophosphate (PRPP) and glutamine into phosphoribosylamine and glutamate, initiating the purine biosynthetic pathway. This enzyme is regulated by various factors, including the availability of its substrates and the end products of the purine synthesis pathway. Its activity is vital for maintaining the balance of nucleotide pools in cells, influencing cellular functions such as cell growth and division.