Gastrointestinal stromal tumors (GISTs) are a type of tumor that occurs in the digestive tract, most commonly in the stomach and small intestine. They arise from interstitial cells of Cajal or precursor cells, which are part of the gastrointestinal system. GISTs can vary in size and may be benign or malignant, often causing symptoms like abdominal pain or bleeding. These tumors are often diagnosed through imaging tests and confirmed with a biopsy. Treatment typically involves surgery to remove the tumor, and targeted therapies, such as imatinib, may be used for advanced cases. Early detection is crucial for better outcomes.