Gamma-enolase is an enzyme that plays a crucial role in the glycolytic pathway, which is the process cells use to break down glucose for energy. Specifically, it catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate, facilitating the production of ATP, the energy currency of the cell. This enzyme is primarily found in the brain and muscle tissues, where it is essential for energy metabolism. Additionally, gamma-enolase is a marker for certain types of tumors, particularly in neuroblastoma, making it significant in medical diagnostics and research.