Filaggrin is a protein found in the outer layer of the skin, specifically in the epidermis. It plays a crucial role in maintaining skin barrier function by helping to aggregate keratin filaments, which are essential for skin structure and resilience. This protein also contributes to the hydration of the skin by breaking down into amino acids that attract moisture. Deficiencies in filaggrin can lead to various skin conditions, such as eczema and ichthyosis. These conditions often result in dry, flaky skin and increased susceptibility to irritants and allergens. Understanding filaggrin's function is important for developing treatments for these skin disorders.