Direct transmission refers to the immediate transfer of pathogens, such as viruses or bacteria, from one person to another. This can occur through physical contact, such as touching, kissing, or sexual activity, where germs are passed directly from an infected individual to a healthy one. Another common method of direct transmission is through respiratory droplets. When an infected person coughs, sneezes, or talks, tiny droplets containing pathogens can be inhaled by someone nearby, leading to the spread of illnesses like the flu or COVID-19.