A cytokine storm is an overreaction of the immune system, where the body releases an excessive amount of cytokines, which are proteins that help regulate immune responses. This can lead to widespread inflammation and damage to tissues and organs, potentially causing severe health issues. Cytokine storms can occur in response to infections, such as COVID-19, or autoimmune diseases. They are often associated with severe cases, where the body's defense mechanisms become harmful rather than protective. Managing a cytokine storm typically involves medications that reduce inflammation and suppress the immune response.