Cyclooxygenases, commonly known as COX, are enzymes that play a crucial role in the conversion of fatty acids into prostaglandins, which are important signaling molecules in the body. There are two main types of cyclooxygenases: COX-1 and COX-2. COX-1 is generally involved in maintaining normal physiological functions, such as protecting the stomach lining and supporting platelet function, while COX-2 is primarily associated with inflammation and pain. These enzymes are significant in the context of pain relief and inflammation management. Nonsteroidal anti-inflammatory drugs, or NSAIDs, work by inhibiting cyclooxygenases, thereby reducing the production of prostaglandins. This action helps alleviate symptoms of conditions like arthritis and other inflammatory disorders, making cyclooxygenases a key target in pain management therapies.