Connexin 43 is a protein that forms gap junctions, which are channels that allow communication between adjacent cells. It plays a crucial role in various tissues, including the heart, brain, and skin, by facilitating the transfer of ions and small molecules. This communication is essential for maintaining tissue homeostasis and coordinating cellular activities. In the heart, Connexin 43 is vital for electrical signaling, helping to synchronize heartbeats. Abnormalities in this protein can lead to various health issues, including cardiac arrhythmias and other diseases. Understanding Connexin 43 is important for developing potential therapies for these conditions.