Zellweger Syndrome is a rare genetic disorder that affects the body's ability to break down certain fats, leading to a buildup of toxic substances. It is part of a group of disorders known as peroxisomal biogenesis disorders, which result from mutations in genes responsible for the formation and function of peroxisomes, small organelles in cells that help metabolize fatty acids. Symptoms of Zellweger Syndrome typically appear in infancy and can include developmental delays, seizures, and liver dysfunction. The condition is often diagnosed through clinical evaluation and genetic testing. Unfortunately, the prognosis is generally poor, with many affected individuals not surviving past early childhood.