The Yukon-Koyukuk Census Area is located in the interior region of Alaska, covering a vast area of approximately 147,000 square miles. It is known for its remote wilderness, including parts of the Yukon River and the Koyukuk River, which are significant for transportation and fishing. The area is sparsely populated, with small communities such as Galena and McGrath. The economy of the Yukon-Koyukuk Census Area is primarily based on subsistence activities, including hunting, fishing, and gathering. The region is rich in natural resources, with opportunities for mining and tourism. Its unique cultural heritage reflects the traditions of the Athabascan people and other indigenous groups.