Waldenström macroglobulinemia is a rare type of blood cancer characterized by the overproduction of a specific protein called IgM (immunoglobulin M) by abnormal plasma cells in the bone marrow. This condition can lead to various symptoms, including fatigue, weakness, and problems with blood circulation due to the thickening of the blood. Patients with Waldenström macroglobulinemia may also experience complications such as anemia, frequent infections, and bleeding issues. Diagnosis typically involves blood tests, imaging studies, and a bone marrow biopsy. Treatment options may include chemotherapy, targeted therapy, and plasmapheresis to reduce the excess IgM levels.