Upper Motor Neuron Disease refers to a group of conditions that affect the upper motor neurons, which are nerve cells in the brain and spinal cord responsible for controlling voluntary muscle movements. Damage to these neurons can lead to symptoms such as muscle weakness, stiffness, and spasticity. Common conditions associated with upper motor neuron disease include Amyotrophic Lateral Sclerosis (ALS) and Primary Lateral Sclerosis (PLS). Diagnosis typically involves clinical evaluation, imaging studies, and electromyography to assess nerve and muscle function. Treatment focuses on managing symptoms and improving quality of life, often involving physical therapy, medications, and supportive care.