Uncoupling Protein 3 (UCP3) is a protein found in the mitochondria of cells, primarily in skeletal muscle and brown adipose tissue. It plays a role in regulating energy metabolism by dissipating the proton gradient generated during cellular respiration, which can lead to heat production instead of ATP synthesis. This process is known as uncoupling, and it helps to manage energy expenditure and thermogenesis. Research suggests that UCP3 may be involved in protecting cells from oxidative stress and regulating fatty acid metabolism. Its expression can be influenced by factors such as diet, exercise, and temperature, making it an important player in energy balance and metabolic health.